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First transplanted human organ grown from adult stem cells
In 2008 the first full transplant of a human organ grown from adult stem cells was carried out by Paolo Macchiarini, at the Hospital Clínic of Barcelona on Claudia Castillo, a Colombian female adult whose trachea had collapsed due to tuberculosis. Researchers from the University of Padua, the University of Bristol, and Politecnico di Milano harvested a section of trachea from a donor and stripped off the cells that could cause an immune reaction, leaving a grey trunk of cartilage. This section of trachea was then "seeded" with stem cells taken from Ms. Castillo's bone marrow and a new section of trachea was grown in the laboratory over four days. The new section of trachea was then transplanted into the left main bronchus of the patient.[55][56][57][58][59] Because the stem cells were harvested from the patient's own bone marrow Professor Macchiarini did not think it was necessary for her to be given anti-rejection (immunosuppressive) medication and when the procedure was reported four months later in The Lancet, the patient's immune system was showing no signs of rejecting the transplant.[60]
In recent years, acceptance of the concept of adult stem cells has increased. There is now a theory that stem cells reside in many adult tissues and that these unique reservoirs of cells are not only responsible for the normal reparative and regenerative processes, but are also considered to be a prime target for genetic and epigenetic changes, culminating in many abnormal conditions including cancer.[61][62] StemEnhance™ is a blend of two compounds extracted from an aqua botanical (water plant) called AFA. One extract supports the natural release of adult stem cells from the bone marrow into the bloodstream and the other supports the migration of adult stem cells out of the bloodstream into the tissues where they are needed. The National Institute of Health has recently stated that Cardio-Vascular health is measured by the number of Stem Cells circulating in the blood. One Gram of StemEnhance™ equals 2 capsules which triggers 25% or 3 –4 million additional circulating stem cells according to research. Traditional health supplements nourish existing cells. They do not create new cells. Science has just recently discovered that the ONLY SYSTEM KNOWN that actually rebuilds the body is your own adult stem cells.
StemEnhance™
Adult Stem Cells…. Rebuild, Renew and Rejuvenate.
Posted in Stem Cell Research on Tue November 14, 2006
Scientists have used stem cells from human bone marrow to repair defective insulin-producing pancreatic cells responsible for diabetes in mice. The treatment also halted damage to the kidneys caused by the condition. Posted in Stem Cell Research on Wed January 25, 2006 A multidisciplinary team of researchers at the Indiana Center for Vascular Biology and Medicine is experimenting with a novel adult stem cell therapy, using patients' bone marrow cells that are involved in arterial formation and repair. The Stem Cell Mediated Angiogenesis Study is an FDA-approved Phase I clinical trial to examine how safe and effective adult stem cells are for stimulating the development of new blood vessels in the legs of patients with severe peripheral vascular disease--a painful condition that, according to the American Heart Association, affects approximately 12 million people. When blocked or destroyed, arteries in the leg are unable to transport essential nutrients and oxygen, resulting in tissue death and gangrene. Many patients suffering from advanced peripheral vascular disease often exhaust all conventional means of therapy and face amputation. Researchers Regenerate Heart Tissue Posted in Stem Cell Research on Fri May 30, 2003 Researchers at the University of Florida have successfully created healthy mouse heart muscle cells from adult bone marrow stem cells. Unlike skeletal muscle, cardiac muscle is unable to repair itself, therefore when it is damaged the damage is permanent. Being able to repair damaged cardiac muscle could save the lives of millions of people throughout the world whose heart muscles has been damaged by disease. Posted in Stem Cell Research on Fri May 30, 2003 Results of a recent study suggests that stem cells could help to repair some of the damage caused by multiple sclerosis (MS). Drs Gianvito Martino and Angelo L. Vescovi of the San Raffaele Scientific Institute in Milan, Italy, injected neural stem cells obtained from adult mice into the brains of mice with an experimental form of MS. Results showed that the stem cells homed in on damaged tissues and proceeded to mature into myelin-producing cells within just 30-days. 30% of mice recovered, while the condition of the remaining 70% improved significantly. The researchers hope to begin non-human primate studies of the potential treatment within two months. If further studies are successful they estimate that therapeutic applications for humans might be available within five to ten years. SOURCE/REFERENCE: Reported by www.reutershealth.com on the 16th April 2003 Posted in Stem Cell Research on Thu September 16, 2004 From Betterhumans, news of research suggesting that adult stem cells can be used to regenerate the damage caused by certain kinds of degenerative blindness. "Stem cells, injected into the eyes of mice with a model of retinitis pigmentosa, lead to the development of blood vessels. Some stem cells were found to incorporate into the vasculature of the retina while others took up residence very close to blood vessels. This provided a protective effect, rescuing and stabilizing the retinal vessels when they would otherwise degenerate." As scientists experiment with adult stem cells - an uncontroversial and thus well supported field - we can expect to see more of these sorts of potential therapies come to light. Posted in Stem Cell Research on Fri June 11, 2004 CORDIS reports on a new integrated European science project aimed at bringing regenerative medicine (based on adult stem cells) for bones, cartilage, and ligaments from basic research all the way to clinical applications. "Over 50 million European citizens suffer from some form of connective tissue disorder. Age-related degenerative disorders (such as osteoporosis, osteoarthritis) are among the diseases with the highest socio-economic impact, requiring hospitalisation, rehabilitation and home care." Projects like this demonstrate that real progress has been made in stem cell basics. The scientific and business communities see a clear path forward, and are starting to move more rapidly. Posted in Stem Cell Research on Tue October 31, 2006 Researchers at Johns Hopkins have shown that transplanting human stem cells into spinal cords of rats bred to duplicate Lou Gehrig's disease delays the start of nerve cell damage typical of the disease and slightly prolongs life. The grafted stem cells develop into nerve cells that make substantial connections with existing nerves and do not themselves succumb to Lou Gehrig's, also known as amyotrophic lateral sclerosis (ALS). The study is published in this week's issue of Transplantation. "We were extremely surprised to see that the grafted stem cells were not negatively affected by the degenerating cells around them, as many feared introducing healthy cells into a diseased environment would only kill them," says Vassilis Koliatsos, M.D., an associate professor of pathology and neuroscience at Hopkins. Posted in Stem Cell Research on Tue December 05, 2006 The team from the University of Manchester hope their treatment will be available within three years. They are perfecting a way to rebuild the soft shock-absorbing discs which separate the vertebrae in the spine. Posted in Stem Cell Research on Wed May 03, 2006 The discovery that bone-marrow derived stem cells can regenerate damaged renal cells in an animal model of Alport syndrome provides a potential new strategy for managing this inherited kidney disease and offers the first example of how stem cells may be useful in repairing basement membrane matrix defects and restoring organ function. Led by researchers at Beth Israel Deaconess Medical Center (BIDMC), the findings are described in the Proceedings of the National Academy of Sciences (PNAS), which appears on-line the week of April 24, 2006. Symptoms of Alport syndrome, the second most common genetic cause of kidney failure, usually appear in children, affecting the kidneys' filtration system and typically leading to end-stage renal disease in the patient's teens, 20s or 30s. The disease additionally causes deafness in some patients.
Researchers from New Orleans' Tulane University are hopeful it can be adapted to treat diabetes in humans. The study, featured in Proceedings of the National Academy of Sciences, was welcomed as "interesting work" by Diabetes UK.
Stem cells are immature cells which have the capacity to turn into any kind of tissue in the body.
The US team treated diabetic mice who had high blood sugar and damaged kidneys. One group of mice were injected with stem cells. After three weeks they were shown to be producing higher levels of mouse insulin than untreated mice and had lower blood sugar levels. The injections also appeared to halt damaging changes taking place in the glomeruli, the bulb-like structures in the kidneys that filter the blood.
Researcher Dr Darwin Prockop said: "We are not certain whether the kidneys improved because the blood sugar was lower or because the human cells were helping to repair the kidneys.
"But we suspect the human cells were repairing the kidneys in much the same way they were repairing the insulin-producing cells in the pancreas."
Tapping The Potential Of Adult Stem Cells
Researchers hope that the specialized adult stem cells--known as endothelial progenitor cells (EPCs), involved in the repair of the inner lining of blood vessels--will help restore enough blood flow to lower limbs to help regenerate blood vessels and avoid amputation. One day, the innovative therapy might benefit other areas of the body, such as the heart muscle.
To learn more about the trial, the Post spoke with Michael Murphy, M.D., at the Indiana Center for Vascular Biology and Medicine at Indiana University School of Medicine.
Post: Could you outline your research utilizing adult stem cell-based therapy to treat cardiovascular disease?
Murphy: Basically in the last five years, researchers have isolated a cell in the bloodstream of humans called an endothelial progenitor cell--a special type of stem cell. Subsequent studies have demonstrated that the endothelial progenitor cell, or EPC, comes from the bone marrow. Clinical evidence from an NIH study showed that patients who have a greater number of cardiovascular risk factors--high blood pressure, diabetes or cigarette smoking--have fewer endothelial progenitor cells. The conclusion was that these cells are involved with arterial repair and may help prevent the development of atherosclerosis. The cells also participate in the development of new blood vessels. Animal studies have demonstrated that when EPCs from bone marrow are injected into lab animals, they develop new blood vessels in response.
Study co-author Dr Barry Byrne and his colleagues found that human bone marrow stem cells differentiated into heart muscle after being injected into the coronary arteries of immunodeficient mice. Tests showed that the new muscle cells were functional and had the same physical characteristics as mouse heart cells. In fact, just two weeks after injection, the new muscle cells were indistinguishable from the animals own rod-shaped heart muscle cells. Previous studies have demonstrated that mouse bone marrow stem cells could be transformed into mouse heart muscle, however this study was the first if its kind to show that human stem cells could be transformed into mouse heart muscle.
Stem Cells Repair Multiple Sclerosis Damage
Stem Cells Regenerate Retinas
The Genostem Project
Human Stem Cells Delay Start Of Lou Gehrig's Disease In Rats
Stem cell cure hope for back pain
Damage to these intervertebral discs (IVDs) is a common cause of debilitating low back pain which affects around 12 million in the UK. A treatment which effectively cured the problem could potentially save the UK economy as much as £5 billion a year.
The new therapy, developed by Dr Stephen Richardson, uses mesenchymal stem cells (MSCs) from adult bone marrow to regenerate spinal discs. MSCs are a class of stem cell which can grow into many different cell types, including bone, cartilage, fat and muscle. Dr Richardson has succeeded in turning MSCs into the cells which make up the gel-like nucleus pulposus (NP) tissue separating the vertebrae. He plans to begin pre-clinical trials next year, with full patient trials to follow on.
Research Finds Bone-Marrow-Derived Stem Cells Can Reverse Genetic Kidney Disease
YOU CAN SEE WHY WE ARE SO EXCITED ABOUT ADULT STEM CELLS!!